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semester 3 syllabus Flipbook PDF
semester 3 syllabus
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Semester III Foundation Course II Experimental Zoology, Instrumentation Biostatistics and Bioinformatics Course Code: ZO. 1341 No. of Credits - 3 Total hours 54 Aim of the course To introduce the methodology and perspectives of Science in general so as to enable thestudents to systematically pursue Zoology in relation to other disciplines that come under the different branches of science. Objectives of the course To learn the fundamental characteristics of science as a human enterprise To understand how science works To study to apply scientific methods independently Module. I Nature and scope of Zoology: 7 Hrs. Branches of Zoology, Opportunities to a Zoologist, Institutes of Zoological and Scientific importance in India- Location, major achievements and present activities (academic and scientific) [Zoological Survey of India. Central Marine Fisheries Research Institute, Central Institute of Fisheries Technology, Rajiv Gandhi Centre for Biotechnology, Bioinformatics Centre and Library, Indian Institute of Science. Stem Cell Institute, National Institute of Immunology, Centre for Cellular & Molecular Biology, Centre for DNA Fingerprinting and Diagnostics, Central Drug Research- Institute]. Module - II Instrumentation (Principle Working and Application) 12 hrs Methods in Biological Science and Solutions Microscopes: Types of microscopes- Dissection microscope, Light microscope, Dark field microscope,. Fluorescent microscope, Phase contrast microscope, Electron microscope (SEM, TEM); Microtome (Different Types),.Embedding, sectioning and staining techniques of light microscopy. Photometry: Colorimetry and Spectrophotometry, Autoradiography: Principle, mechanism, and significance; Centrifugation: Principle and applications; Chromatography: Principle and uses. Module – III Biostatistics and Experimental Science. 16hrs Introduction to Biostatistics: Variable and-attribute; Population vs. Sample; Census vs. Sample survey; Arrangement of data; Frequency distribution.
Graphical presentation of data: Line diagram; Bar diagram; .Pie chart; Histogram. Measures of central tendency: Arithmetic mean; Mode; Median. Measures of dispersion: Variance; Standard deviation; Standard error of mean; Standard score. Testing of hypothesis and goodness of fit: Null hypothesis, Level of significance, Probability, Normal distribution, Error of inference, Student's t-test, Chi-square test.
BIOINFORMATICS
Dr Gayathri Elayidam U
Module IV 4 hrs Overview of Information Technology: features of the modern Personal Computer and Peripherals computer networks and Internet. Introduction to Operating System. DOS/ Windows. Linux. Purchase of technology, license. guarantee. warranty. Module V
7hrs
Definition, Nature & Scope of Bioinformatics - Contrast between Bioinformatics and Computational Biology; Key Bio-sequences in Molecular Biology - DNA, RNA and Aminoacid sequences. Popular Databases in Bioinformatics – NCBI, DDJB, PDB, OMIM; BLAST & FASTA sequence file formats, Approach of Comparative Biology based on sequence comparison - The basic idea of sequence comparison (algorithms not required) - idea of scoring matrices Module VI
8 hrs
The Blast search engine - important features - Idea of Multiple sequence alignment -Proteomics: Basic ideas of Protein Structure prediction- Concept of Homology Modeling- Idea of Molecular Phylogenetics - 'advantages and computational procedure (only description of use of a package such as Phylip). Basic concepts of computer Aided. Drug .Diseovery. General description of drug discovery pipeline concept of Personalized medicine; Bioinformatics tools: (i)Molecular Visualization Software - Rasmol (Basic features only) - (ii) ORF finding (iii) gene finding, (iii) BLAST (iv) Hydrophobicity Prediction (v) Single Nucleotide Polymorphism (SNP) prediction using GENSNIP. Central Drug Research Institute
NB: Assignments/ Seminar - Topics related to syllabus can be given to students as assignment/- seminar. References Aggarwal, S.K. (2008) Foundation course in Biology. Ane Books India, New Delhi. Arora PN and PK Malhotra (19%) BiosuniSties. Himalaya Publishing House. Arthur. M. Lesk (2000) Introduction to Bioinformatics, Oxford publishers. Bajpai, P. K. (2008) Biological instrumentation and methodology. S. Chand and Company Ltd. Claveriere and Notredame. (2003) Bioinformatics, a beginner’s Guide. Wiley and Dreamteh, India Pvt. Ltd. Collins H. and Pinch, T. (1993) The Golem: What everyone should know about Science. Cambridge university press. Debbie Holmes, Peter Moody and Diana Dine. (2006) Research methods for the biosciences, International students' edition. Oxford university press. Gieryn, T.F. (1999) Cultural Boundaries of Science. University of Chicago press Graeme. D. Ruxton and Nick Colegrave. (2006) Experimental design for the life sciences, 2nd edition. Oxford University press. Gurumani. Research Methodology. M.J.P.Publishers, Chennai, 600 005 Keith Wilson and John Walera. (2008) Principles and techniques of biochemistry and Molecular Biology. Cambridge University press. Norman,T.J. Bailey (2007) Statistical methods in biology, 3rd edition. Cambridge university press. Sokal & Rohif(1973) Introduction to Biostatistics -Toppan Co-Japan Veerbala Rastogi. (2008) Fundamentals of biostatistics. Ane booksindia. Chennai.