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Name: Address: Tel: Date: Vet’s name: Address: MDR-1 and Collies You are probably aware that the Rough and Smooth Collie

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Name: Address:

Tel: Date: Vet’s name: Address:

MDR-1 and Collies You are probably aware that the Rough and Smooth Collie are one of a number of breeds that may be affected by the mutant MDR-1 gene. It is now widely accepted that the collie breeds (Rough Collies, Smooth Collies, Shelties and Border Collies) appear to be hypersensitive to certain drug compounds that even in minute doses can cause severe, sometimes lethal, toxicity. I have had _____________________________, tested and he/she is known to be unaffected/affected/a carrier (delete as appropriate) I would be grateful if you could attach this information to his/her record for information as it indicates that there are currently no drug groups likely to cause problems. Yours sincerely

Class A

DO NOT USE in dogs with MDR1 Anti-Parasitic Drugs  Ivermectine defect (-/-) substances: Diapec®, Ecomectin®, Equimax®,Eqvalan®, Ivomec®, Affected dogs carry two mutant Noromectin®, Paramectin®, Qualimec®, MDR1 genes and can therefore Sumex® & Virbamec® only pass on a mutant gene to their offspring. Affected dogs Doramectine substances: Dectomax® will experience drug toxicity Moxidectine substances: Cydectin® & following normal doses of Equest®    (EU scientists commonly find certain drugs, listed here residues of the above drugs in animal products - milk, cows, sheep, pigs & salmon). Loperamide substances: Immodium® [antidiarrhoeal] Metronidazole substances: Flagyl

Class B

Interactions have been shown. Use only under close supervision of your vet

Cytostatics:(Cancer treatment) Vinblastine, Doxorubicine, Paclitaxel, Docetaxel, Methotrexat & Vincristine Glucocorticoids (Steroids commonly used to treat auto-immune diseases): Dexamethason Immuno-suppressives: Cyclosporine A Heart glycosides: Digoxine & Methyldigoxine Antiarrhythmics: Verapamil, Diltiazem & Chinidine [Heart problems] Pain control: Morphine & Butorphenol Anti-emetics: Metoclopramide, Ondansetron & Domperidon [sickness/vomiting] Antibiotics: Sparfloxacin, Grepafloxacin; Erythromycin Antihistamines: Ebastin   Tranquillisers & pre-anaesthetic agents: Acepromazine

Analgesic & pre-anaesthetic agent: Butorphanol Other drugs; Etoposide; Mitoxantrone; Ondansetron; Paclitaxel;Rifampicin. Class C

Can be used

Stronghold®, Advocate® & Milbemax® can be used safely, but only in the recommended application form and dosage. *In dogs with an MDR1 mutant gene [-], Acepromazine and Butorphanol tend to cause deeper and more prolonged sedation. Vets are recommended to reduce the dosage by 25% in MDR1 carriers [+/-] and by 30 -50% in MDR1 affected dogs [-/-]

Last updated – August 2010 (Smooth Collie Club of Great Britain)