LUMENIS’ 50TH ANNIVERSARY CELEBRATIONS Special Edition

April 2017

CEO Opening Dear colleagues and friends, Welcome to this special 50th anniversary edition of Spotlight! I would like to dedicate the pages to come to the remarkable 50-year history of Lumenis and raise a toast to the people and technologies that have helped define the medical device industry and build Lumenis into the global leader we are today. Just to provide a bit of context, when we got our start with the first Coherent laser in 1966, The Sound of Silence by Simon & Garkfunkel was the #1 song on the billboard charts, The Sound of Music won the academy award for best picture and preparations for the moon landing were still ongoing. As new musicians, movie stars and milestones have come along, Lumenis has remained a constant – a model of longevity, redefining the world of noninvasive energy-based healthcare, one innovation at a time. From the first laser photocoagulator to the CO2 laser, from SLT to Holmium Urology and IPL, our industry is defined by the technologies and solutions conceived and pioneered by Lumenis. Connecting all these different technologies is one common goal – to always be the best, work with the best and provide the best; a perpetual commitment to innovation and quality, and to the partnerships with leading figures and institutions in the medical community that combined enable us bring to market premium solutions, with superior clinical outcomes for patients all around the world. From a product, technology and clinical perspective, meeting this lofty standard requires the ability to leverage both internal and external innovation capabilities. With this in mind, I would like to take this opportunity to formally and proudly announce the recent extension of Lumenis’ technology through the addition of both Pico-Second and Nano Q-Switch lasers to our suite of premium Aesthetic solutions. This unique and industry-leading technology comes to us after 20+ years of development by the American device manufacturer Focus Medical, and enables the extension of our premium reach to a new and exciting domain. On the internal front, Lumenis proudly showcased its latest innovation in Urology at the recent EAU congress, the new Moses Holmium. The unique Moses Holmium technology allows us to take holmium laser lithotripsy, first pioneered by Lumenis in the early 1990s with the VersaPulse system, and later disrupted again in 2014 with the game-changing Pulse 120H, to an entirely new level. On the other side of being the best, is providing the best – while technology is our foundation, delivering it to practitioners and patients around the world requires sales and execution of the highest caliber. And with our 50-year history comes a robust sales presence in over 100 countries, an industry-leading and internationally recognized service organization and a brand name synonymous with lasers, quality and longevity – that all allow us to do just that.

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Lumenis’ 50th Anniversary Celebrations | March 2017

Ceo Opening And most importantly, veiled behind all the innovation, all the achievements and all the history, are the people. Lumenis is truly a dynasty, with generations new and old, that have contributing to changing the world and setting a new global standard for noninvasive healthcare – delivering better technology for better patient care! To our dedicated teams in the Americas, APAC, EMEA, Japan, and to our amazing team in Israel – I would like to thank you for your outstanding contributions and for being a part of this great Lumenis family. Thank you for all that was and all that will be, and to all those that made, and will continue to make it happen! Cheers! Yours truly, Tzipi

Table of

CONTENTS CEO Opening

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Light of Life – Lumenis Story

4

Aesthetic Technologies & Treatments

5

Surgical Products Development

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Ophthalmic Innovation Over Time

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A Heritage of Innovation

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KOL’s Journey with Lumenis

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Lumenis Veterans

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Lumenis Around the Globe

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Lumenis’ 50th Anniversary Celebrations | March 2017

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Light of Life Lumenis Story

Light of Life Lumenis Story Lumenis, the Light of Life, is the world’s leader in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets. For us, light is not only a central pillar to our technological innovations, but also a symbol of our commitment to improving the health and well-being of our patients. With its advanced technologies, goldstandard products and revolutionary treatment methods, Lumenis has made its global footprint and changed the face of healthcare forever. Innovation is the foundation of Lumenis’ history. In 1966, Coherent was founded with the creation of the first medical laser for ophthalmology. Coherent was the first company in the world to successfully commercialize a laser-based medical system. In the years to follow, Sharplan was founded and introduced new medical lasers: UltraPulse® CO2 laser, Nd: YAG laser, 920 Argon / Krypton laser, VersaPulse® Holmium laser and Novus™ 2000 laser. In the 90’s, ESC was founded and launched The Ultima™ 2000 laser series, few years later, the company acquired Luxar™ and introduced Selecta™ 7000 (SLT™). The merger of ECS™ & Sharplan™ created the introduction of LightSheer® DUET™, UltraPulse Encore, IPL Quantum™ and VersaPulse PowerSuite™. Lumenis was formed on 2001 through the merger of Coherent & ESC / Sharplan. Today, Lumenis holds more than 220 patents for its technologies and has earned numerous FDA clearances over the course of its 50 years of research and development. With an active installed base of more than 80,000 systems, presence in over 100 countries, strong brand and partnership with KOL and more than 1,000 professionals worldwide, Lumenis continually pushing the bboundaries of excellence and innovation!

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Aesthetic Technologies & Treatments

Aesthetic Technologies & Treatments In the 1990’s CO2 laser resurfacing was considered the gold standard for treatment of acne scarring and photodamaged skin. These lasers had considerable post-procedure problems including long recovery time high ratio of adverse side effects. Significant advancement has been made in aesthetic laser industry with the introduction of Intensed Pulse Light (IPL) technology in 1993, invented by ESC, which soon after became Lumenis. By using a range of wavelengths and a clever algorithm, IPL could treat many ailments at once. In 1998, a new concept of multi-applications systems was introduced with the launch of Vasculight ®. These systems started a trend of non-invasive procedures with lower downtime and associated risks, which is on a constant rise since then with a growing patients’ demand, leading to today’s best-selling system of Lumenis, the M22, that incorporates 4 different non-ablative technologies, offering different ways to rejuvenate the skin, with minimal downtime, and maximum comfort to the patient.

less adverse events, while introducing new options for skin rejuvenation treatments. In 2012 the UltraPulse SCAARFX was released- the world’s first fractional CO2 to impact up to 4mm in depth for effective treatment of scars. This treatment proved to be life changing for many severe scars patients. In the recent years, the use of CO 2 lasers started expanding to new areas. In 2015 Lumenis introduced FemTouch, a vaginal CO2 laser procedure for women’s health. This innovative laser procedure delivers CO2 laser to the vaginal wall, allowing stimulation of new tissue growth, by triggering collagen production.

With these new developments, physicians can now offer a large variety of skin treatments, tailored to their patients’ needs. Another revolutionary breakthrough happened in the 2000’s with the release of fractional CO2 lasers. In 2005, Lumenis released the UltraPulse ActiveFX – the world first fractional CO2 laser, followed by the UltraPulse DEEPFX, the world’s first micro-fractional CO2 laser. These new fractional CO2 features enabled lower downtime, with

Lumenis’ 50th Anniversary Celebrations | March 2017

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Surgical Products Development

Surgical Products Development For years, Lumenis have redefined medical treatments and set numerous technological and clinical gold-standards, successfully designing advanced technologies that have revolutionized existing treatment methods. Providing 2 Offerings to Various Market Segments Each of the Pulse laser systems offer exceptional performance within its category, resulting in safe, efficient and advanced patient care.The three new laser systems join the Lumenis Pulse 120H platform, together creating an unparalleled and comprehensive product line. The Lumenis Pulse 100H, the next generation of the VersaPulse® PowerSuite™ 100 Watt system, is a versatile and enhanced laser solution for the treatment of a wide range of clinical urological indications. The Lumenis Pulse 50H provides more than 130 different energy and frequency settings, it is capable of addressing any size and type of stone and soft tissue quickly and effectively. The Lumenis Pulse 30H, features energy per pulse of up to 5J, the highest of its kind, along with a repetition rate of 25Hz. This allows reduced procedure duration, higher

stone fragmentation rate, minimal retropulsion, and maximizes the number of different types and sizes of stones, setting it apart from all competition in this power category.

Revolutionizing Holmium Lasers & Fibers in Urology Moses™, a new breakthrough patent pending technology redefines holmium lithotripsy technology as it exists today. Moses™ technology includes a proprietary combination of holmium lasers and fibers that optimize holmium energy transmission allowing the surgeon more control regardless of the working distance between the fiber and the stone. Leading physicians who initially experience with Moses™ were very excited about it and commented that it is a true breakthrough. Introducing the World the Only Integrated CO2 Laser Platforms The launch of AcuPulse™ DUO marked the breakthrough of the DUO platforms to market, by being the only integrated CO2 laser system that allows surgeons to switch between fiber and free beam modalities electronically. Addressing a broad range of clinical solutions for ear, nose and throat, gynecology, otology and general surgery, AcuPulse DUO enabled surgeons to tailor treatment for each patient providing them the versatility to choose the right treatment for their patients.

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Ophthalmic Innovation Over Time

Ophthalmic Innovation Over Time Lumenis vision is one of the world leaders in non-refractive eye care lasers. We pride ourselves with a long impressive history of innovation, starting with the introduction of the very first ophthalmic Argon photocoagulator 50 years ago. Following this, Lumenis vision invented Selective Laser Trabeculoplasty (SLT) that became a global standard of care for laser Glaucoma treatment, was the first to introduce YAG laser treatment in ophthalmology and many more.

Today, we continue our legacy of innovation and proudly introduce the newest green photocoagulator in the market Smart532™, 100% developed and brought to market by Lumenis. Smart532™ incorporates SmartPulse™, the most advanced sub-threshold technology in the market. Lumenis vision is strongly committed to keep on bringing better technology for better eye care.

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A Heritage of Innovation

1966

1970

1973

1980

1982

Coherent founded

Developed world’s first argon photocoagulator for ophthalmology

• Sharplan founded • First CO2 surgical laser supplied to Albert Einstein Hospital

Introduced SuperPulse™ CO2 laser, established as the standard in modern laser applications

Introduced Nd:YAG laser model 9900, the world’s first photodisruptor for ophthalmology

1993

1994

1995

1996

Invented IPL® (Intense Pulsed Light)

Introduced Novus® Omni™, the world’s f irst ophthalmic laser

Introduced PhotoDerm® VL

Introduced VersaPulse® C

A Heritage of Innovation

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2002

2003

2004

Introduced: • Novus® Varia™, the world’s first diode-pumped multicolor photocoagulator • Selecta® Duet™, world’s first combination SLT/Nd:YAG laser

Introduced Lumenis One™, world’s first customizable platform for aesthetic procedures

Introduced Q-Switched Nd: YAG treatment head for tattoo removal

2010

2011

2012

Introduced VersaPulse P20

Introduced Vision One OPSL MultiWavelength Photocoagulator

Introduced: • AcuPulse WaveGuide • Array™ LaserLink™ • SCAAR FX™ for treatment of scars

Lumenis’ 50th Anniversary Celebrations | March 2017

A Heritage of Innovation

1983

1985

1990

1990

Introduced model 920 Argon/Krypton laser, the world’s first multicolor photocoagulator for ophthalmology

Introduced model 920 Dye laser, the world’s first wavelength-tunable photocoagulator for ophthalmology

Introduced: • UltraPulse® CO2 and VersaPulse ® Holmium laser systems • Novus 2000 ®, the world’s first dual-fiber • Patented waveguide delivery system for CO2 laser.

ESC Founded

1998

1999

2000

2001

• ESC acquired Luxar

• ESC and S  harplan  merged Introduced: • VascuLight® • LightSheer®  for hair removal • UltraPulse ® Encore™ CO2 laser for skin  resurfacing

Introduced: • VersaPulse® PowerSuite™, world’s first 100W Holmium laser for BPH • Opus5™ and Opus10™ diode laser systems • IPL® Quantum™ f or Photorejuvenation

Lumenis formed through merger of Coherent Medical Group and ESCSharplan

2006

2007

2008

2009

• Acquired SRT™ technology • Introduced ActiveFX™ fractional CO2 treatment • Introduced Aura™ PT Nd:YAG Photodisruptor

Introduced DeepFX™ The world’s first micro-fractional CO2

Introduced: • Selecta Family of lasers and New Dual-port Novus® Spectra™ • LightSheer® DUET

Introduced: • AcuPulse™ with SurgiTouch • InSight: Integrated Slit Lamp Delivery System

• Introduced Selecta® 7000 laser for Selective

2013

2014

2015

2016

Introduced: • AcuPulse DUO • FiberLase Robotic DIG • MicroLase Fiber • FiberLase GYN Handpiece • Introduced ResurFX™

• Lumenis on the Nasdaq • Introduced: • Lumenis Pulse 120H • Xpeeda Fiber  • SlimLine 200 D/F/L Fiber • LightSheer® INFINITY

• Pollogen acquisition

Introduced: • Lumenis Pulse 30H • SlimMe • Smart Selecta Duet • Smart 532 • M22 Optima IPL

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• Merger transaction with XIO Group • Introduced: • UltraPulse DUO • Lumenis Pulse 100H • Lumenis Pulse 50H• FemTouch™

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KOL’s Journey with Lumenis

KOL’s Journey with Lumenis “I am fortunate to utilize Lumenis Optima Intense Pulse Light system in my clinic. Lumenis is the company which had the first FDA approved IPL system in the late 90’s, and has gone long way over the years, improving on the design and technology to enable doctors deliver a treatment that is efficacious and safe” Dr. Rolando Toyos

"When we were the first to develop the IPL in the 1990’s it was not clearly understood how a pulsed broadband non laser energy source could treat specific chromophore targets, but through the years it has proven to be one of the most versatile technologies on the market. The invention of these laser and light based approaches for dermatology opened up my practice for a whole new set of aesthetic indications I never had a good solution for. Now I can’t do without them!” Dr. Mitchell P. Goldman

“I was fortunate to receive one of the earliest units available in 1994 and was featured in a local magazine which literally caused the phones to ring off their hooks! The technology revolutionized my practice. Prior to laser skin resurfacing, there were limited treatments available that could safely and effectively improve the appearance of photoaged skin. The pulsed and scanned CO2 laser technology literally brought “Star Wars” medicine to the forefront at a crucial time to address the needs of aging baby boomers. The pulsed and scanned technology opened the doors for the fractionated laser technology we use today” Dr. Tina Alster

“The CO2 laser with high pulse energies and short pulses revolutionized the world of resurfacing. In the lab we measured the impact of pulse duration and irradiance on ablation efficiency, bridging earlier theoretical work with the ever expanding role of pulsed CO2 lasers in clinical dermatology” Dr. E. Victor Ross

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Lumenis’ 50th Anniversary Celebrations | March 2017

KOL’s Journey with Lumenis

“The beginning of my relationship with Lumenis 22 years ago, really set the tone for the kind of access and high character of the individuals and the Lumenis administration have demonstrated over the years. I’ve known quite a number of colleagues in Lumenis and consider several if not many friends, not just colleagues in the process of allowing me to have the best devices in the highest quality of technology that could possibly be used to assist me in taking care of my patients. I believe that the Lumenis Company would do their outmost to give me the best technology that I can have and to take care of them to the highest level of quality that I can give them. I really see a commitment to that groundbreaking attitude at Lumenis. It’s usually about the bottom line not so much about what it is that I need, and to do it in a way that I think anyone of the people of that company would want that for them or for their families. That’s a standard I hold myself to as a surgeon and I think Lumenis examples that as a company” Dr. Paul F. Castellanos

“ESC Medical Systems introduced me to the “laser” business. And with it, the endless possibilities of taking care of my patients in ways I never dreamed. Lumenis has continued that dream, introducing me to their markets all over the world and allowing me to participate in the training of the next generation of laser experts. It has been a remarkable journey – all with the power of light” Dr. Michael Gold

“Pioneering Lumenis devices opened up an entire new realm of aesthetic and medical skin treatment. I feel privileged to have participated in the development of the original first Photoderm IPL and Ultrapulse CO2 laser. These devices transformed the way we treat skin disorders and laid the foundation for decades of innovation in dermatology” Dr. Arielle N.B. Kauvar

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Lumenis Veterans

Lumenis

Veterans Qiying Zhai - APAC President Started working at Lumenis in January 1991 at the position of Service Engineer, Having gained diverse experience through a variety of technological and managerial roles, today Mr. Zhai serves as APAC President. As a leader who grow within the company, his wishes for Lumenis are for us to acknowledge our accomplishments and also to re-energize our commitment to bring life changing products to people around the world.

Remco Schmitz - EMEA Aesthetics Senior Director Joined Lumenis Holland BV in October 2003 as EMEA Supply Chain Director. During his 14 years with Lumenis he held several positions from EMEA Service Director, UK Aesthetics Manager, Regional Sales Manager Eastern Europe and Benelux till today being responsible for the EMEA Aesthetics business as the EMEA Aesthetics Senior Director. Let’s lead the way in R&D and Marketing and build the foundation for the next 50 years! Nir Pialkov – GSO Senior Director Joined Lumenis in August 1986 at the position of Final Tests Technician. Nir describes the first few years as dynamic and wonderful, Lumenis in its previous incarnation was a great place to learn and to grow professionally and personally for a young engineer. Today, after many successful years in different roles in the service field, Nir serves as GSO Senior Director. He is proud to be a part of the company’s tremendous growth and constant advancements in technologies and wishes Lumenis for another 50 prosperous years!

Rashid Mak – Marketing Senior Director Started his Lumenis Journey in January 2006 as a Service Engineer and later on moved to Sales & Marketing head for Surgical BU. Lumenis has evolved over the years from the company known for producing best in class Laser technologies to complete solution providers by integrating laser technologies with high end clinical training tools. Rashid’s wishes for Lumenis is to continue as market leaders!

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Lumenis’ 50th Anniversary Celebrations | March 2017

Lumenis Veterans

Jeff Thompson - Americas Service Senior Director Started working at Lumenis in September 1986 at the position of Field service engineer. The first few years revolved around building an excellent team driven to perfection in both quality and customer care. With all of the advancements in technology, communication and cultural changes that have taken place, one thing remains constant and that is the passion for excellence in all that we do.

Hu Shi Xin – Lumenis China OPH BD Director Started working at Lumenis in February 1995 at the position of Service Engineer. Those years, he supported versatile products such as Novus 2000, Ultima 2000, LDS, UltraPulse 5000c, LightSheer and many more. Since 2014, Hu Shi Xin serves as OPH BD Director and his wishes for Lumenis future years are to invest more in the development of new products.

Su Yuan – APAC Technical support Director Started working at Lumenis in April 1997 at the position of Field service engineer and took upon himself managerial roles in the fields of service and technical support. Today serves as APAC Technical support Director. For our 50th anniversary, his wishes for Lumenis are to have an even brighter future and achieve more unique successes.

LUMENIS EMPLOYEE NEWSLETTER | June 2016 Lumenis’ 50th Anniversary Celebrations | March 2017

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Lumenis Around the Globe

Lumenis

Around the Globe

UK Established: 2000

SALT LAKE CITY USA Current office Established: 2014

SAN JOSE USA Established: 2012

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Lumenis’ 50th Anniversary Celebrations | March 2017

Lumenis Around the Globe

GERMANY

Established: 1992

CHINA Current Office Established: 2000

ITALY Established: 2011

KOREA Established: 2014

JAPAN

Established: 2001

CORPORATE YOKNEAM, ISRAEL Current Office Established: 2010

INDIA Established: 2007

POLLOGEN TEL AVIV, ISRAEL Joined Lumenis: 2015

TAIWAN

Established: 2015

HONG KONG Established: 1991

AUSTRALIA Established: 2012

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